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Toremifene Citrate ?

Toremifene citrate is a selective estrogen receptor modulator (SERM), a class of research chemicals that exhibits affinity for estrogen  receptors but does not have estrogenic activity at the receptor, thereby limiting many of the physiological effects of estrogen.Toremifene is approved under the brand name Fareston for advanced metastatic breast cancer in the USA, and is in trials for approval for use as a prostate cancer preventative under the name Acapodene.[1]

Toremifene and tamoxifen, for different reasons, may be useful in treating cardiovascular disease, as revealed in a Japanese study of early-strage breast cancer treatment via SERMs:

Compared with baseline, at 24 months, the toremifene group (n = 123) showed significantly decreased total cholesterol (P < 0.001) and low-density lipoprotein cholesterol levels (P < 0.001), and significantly increased high-density lipoprotein cholesterol levels (P < 0.001). Their triglyceride levels were not affected (P = 0.677). The tamoxifen group (n = 120) also showed significantly decreased total cholesterol (P < 0.001) and low-density lipoprotein cholesterol levels (P < 0.001); no significant changes occurred in high-density lipoprotein cholesterol (P = 0.297) or triglyceride levels (P = 0.120). CONCLUSIONS: Distinct differences between two selective estrogen receptor modulators on lipids were observed. Toremifene improved lipid profiles, particularly as an enhancer of high-density lipoprotein cholesterol. To a large extent, tamoxifen improved low-density lipoprotein cholesterol levels. The impact of these improved lipid profiles on the risk of cardiovascular diseases needs further confirmation.[2]

Lewis et al concluded from their observations that tamoxifen and toremifene are roughly equally effective in treating breast cancer:

Fareston (toremifene) and tamoxifen, both selective estrogen receptor modulators, are therapeutically equivalent treatments for metastatic breast cancer. We hypothesized that toremifene as compared with tamoxifen given as adjuvant therapy for early stage breast cancer would result in equivalent survival with an improved side effect profile, therefore, providing superior therapeutic efficacy. …Women treated with adjuvant hormonal therapy enjoyed excellent DFS and OS. No significant differences were found between treatment with either tamoxifen or toremifene. Treatment of HR-positive patients with either tamoxifen or toremifene is appropriate.[3]

Tsourdi, comparing 20mg tamoxifen with 80mg toremifene and an equivalent dose of raloxifene, concluded that in treating idiopathic oligozoospermia, tamoxifen and toremifene are roughly equally effective but raloxifene is not.:

The antiestrogenic effects of SERMs at the hypothalamic level result in a statistically significant increase of gonadotropin levels, which is more marked for tamoxifen and toremifene compared with raloxifene.[4]

Another study designed by Farmakiotis et al to “evaluate whether toremifene, a selective estrogen receptor modulator (SERM), has a beneficiary effect on all three main sperm parameters” concluded:

Toremifene administration for a period of 3 months in men with idiopathic oligozoospermia is associated with significant improvements of sperm count, motility, and morphology, mediated by increased gonadotropin secretion and possibly a direct beneficial effect of toremifene on the testes. The above findings are also indicative of a better testicular exocrine (improved sperm parameters) response to treatment in men whose partners achieved pregnancy compared with those who did not. Further randomized, placebo-controlled trials should be conducted to determine whether this particular selective estrogen receptor modulator can be useful as an initial approach in men with oligozoospermia.[5]

Taneja et al write that toremifene has “shown promise in reducing fracture risk in [prostate cancer patients who are receiving androgen deprivation therapy who are at risk of bone issues].”[6]

On the same topic, Egerdie and Saad write:

Osteoporosis and bone fractures are frequently overlooked complications of androgen deprivation therapy in men with nonmetastatic prostate cancer. All such patients should have their bone mineral density (BMD) monitored and be offered preventive measures, such as calcium and vitamin D supplementation; patients with low BMD should be offered treatment. Several agents, including  bisphosphonates, are available (although this use is currently off-label), and upcoming treatments, such as denosumab and toremifene, have shown promise in reducing fracture risk in these patients.[7]

On the topic of prostate cancer prevention, a fairly novel concept, Fitzpatrick et al write:

The long latency period, high disease prevalence, and significant associated morbidity and mortality make prostate cancer a suitable target for a risk-reduction approach. Several agents are under investigation for reducing the risk of prostate cancer, including selenium/vitamin E and selective oestrogen receptors modulators (e.g. toremifene). In addition, the Reduction by Dutasteride of Prostate Cancer Events trial, involving >8000 men, is evaluating the effect of the dual 5AR inhibitor, dutasteride, on the risk of developing prostate cancer. A successful risk-reduction strategy might decrease the incidence of the disease, as well as the anxiety, cost and morbidity associated with its diagnosis and treatment.

*The latter article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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What does TESTOLONE (RAD140) do for a woman?

Researching Testolone

Women may experience an increase in libido and sexual appetite. It is still possible to get pregnant while taking Testolone, however Testolone is toxic for a fetus and you can’t take Testolone while pregnant.

During research  masculinizing  sessions, you’ll be researching the male hormone testosterone, which suppresses the menstrual cycles and decreases the production of estrogen from the ovaries. Changes caused by these research may be temporary . Masculinizing research sessions can be done alone on in combination with masculinizing surgery.

Masculinizing research sessions isn’t for all transgenders, however.  Masculinizing research sessions can affect your fertility and sexual function and cause other health problems. Your doctor can help you weigh the risks and benefits.

SARMs like RAD140 can be better alternatives to T because they are only partial agonists or antagonists to androgenic regulation of prostate while still having androgenic effects on other tissues such as muscle and brain.

Some women try an over-the-counter supplement or gel form of DHEA—a hormone that our body converts into both female (estrogen) and male (androgen) hormones. However, evidence on DHEA’s effectiveness in treating sexual problems in women is mixed.

It is important to note that research in this area is still ongoing.

Low testosterone can cause one or more of the following symptoms in women:

  • sluggishness
  • muscle weakness
  • fatigue
  • sleep disturbances
  • reduced sex drive
  • decreased sexual satisfaction
  • weight gain
  • fertility issues
  • irregular menstrual cycles
  • vaginal dryness
  • loss of bone density

It is important to note that research in this area is still ongoing.

Women with high testosteroneTestosterone is a male sex hormone, or androgen, produced in a woman’s ovaries in small amounts. Combined with estrogen, the female sex hormone, testosterone helps with the growth, maintenance, and repair of a woman’s reproductive tissues, bone mass, and human behaviors.

While there is evidence that  research  masculinizing  sessions can help some women with certain health-related issues, primarily sexual disorders, it most assuredly is not a magic bullet, and it is not recommended for most women. First, a few words about testosteroneTestosterone is an androgen, or sex-related hormone.

Hormone levels continually change, rising and falling even by the minute.  Testosterone levels typically decline with age, both in men and in women. But sometimes, the balance shifts in the opposite direction, and testosterone, rather than drop, will climb.

Excess testosterone can cause wanted or unwanted effects and symptoms for women, including:

  • Menstrual irregularity or absence of periods
  • Excess body hair
  • Hair growth on chin or upper lip (hirsutism)
  • Acne
  • Enlarged clitoris
  • Balding, especially around the hairline
  • Increased muscle mass
  • Changes in body shape
  • Decreased breast size
  • Oily skin
  • Deepening of the voice or hoarseness
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The truth about UG SARMs

Underground sarms  aren’t completely free from side effects they just tend to be minimal at small doses. Bodybuilders  and athletes don’t take small “small doses”,and that’s why they often experience many of the side effects associated with steroid use.

LIST OF POTENTIAL SARM SIDE EFFECTS

Masculinization – Now I’ve seen women steroid users look pretty good then Ive seen some wanna take it to the next level, let’s call it like ultra beast mode leaving them real masculine with a jawline that will make ya look twice for that adam’s apple.Female users pay attention to your body when using SARMS supplements . Steroids can cause the development of masculine features by reducing the femininity of the user, the same can happen when using SARMS supplements. What makes a major difference is the fact that a female would have to use large doses of SARMS for a prolonged period of time in order to experience these symptoms. So take all info with a grain of salt, SARMS are even less harmful than Anavar, which is known in the bodybuilding circles as the best steroid for women due to its mild side effects.

BALDNESS – So before ya just say hey this must be the magic bullet please do your own research because everybody’s different I took some DHEA supplements @ 100 mg per day and are used by some people who believe they can improve sex drive build muscle, fight the effects of aging, and improve some health conditions. So I stacked it with some test booster and  experienced improvements in all the stuff above but noticed my already receding hairline, receding so stopped then cut it to 50mg per day which kept it under control but have not l had that effect with sarms supplements. Your experience on steroids, apply to SARMS as well. The good thing when it comes to balding is that SARMS  supplements are not very androgenic, and balding is associated with products that have higher androgenic properties such as Dianabol and Anadrol. Therefore they are safer to use than steroids in this regard

GYNO– aka bitch tits aka  gynecomastia is what happens when the aromatizing enzyme creates too much estrogen in males when doing  anabolic steroids or even happen during puberty and can be prevented with PTC treatment  to help restore one’s natural testosterone production to bring about a better environment for overall health and to maintain muscle tissue. The fact that SARMS supplements  have a 10:1 anabolic to androgen ratio makes them much safer to use when it comes to bitch tit syndrome or water retention . The estrogen in your body will not raise significantly, but when you jump off any research  the feminizing effects that occurs when taking injectable testosterone or oral pills such as Dianabol don’t have a chance to develop at moderate doses. If these side effects do occur, it is easy to treat them by taking an anti-estrogen.

Overriding  NATURAL TESTOSTERONE – SARMS  supplements  can cause the suppression of natural testosterone when replacing it with a cycle last for a long time and again everybody’s body is different (6-12 weeks, depending on the product is basic or noram ). But one called Ostarine can suppress natural testosterone production in a similar way that Winstrol does, as both products have a highly anabolic effect. A product called SARM S-23 should be avoided for this very reason, as it greatly suppresses testosterone production in the body. Because of these potential side effects, it is advised to do a Post Cycle Therapy after longer cycles, and sometimes even after a cycle of 4-5 weeks as a general precaution.

BLURRED VISION – This side effect has caught the attention of many researchers  on the internet sharing the info learned by trial and error. No one wants to risk their vision for bigger muscles! This is a completely natural response. Some users of Ostarine on internet forums reported having this issue, that resolved after discontinuing the usage of the product. It is interesting that this side effect didn’t occur in clinical trials, but it’s still worth giving ya the head up and let ya know what it might do.

All in all

To sum up the Underground sarms side effects, they are generally the same ones that are associated with using steroids. Do your research and then dig a little deeper .  Younger people should not fuck around like this with their body cause you should be able to work it out with all that young energy , now older folk been fuckin with this cause after a certain age it gets a little harder to make them gains and it’s not  a magic bullet but we may need that extra boost for extra stamina, muscle growth and overall steps to help towards a healthier life.

Now with all that out of the way let’s take a look at all the good stuff Underground sarms can bring to the table.

Why are people taking advantage of these research chemicals?

Let’s start with saying their Non-methylated, anabolic even at low doses, taking your game to next level for strength, lean muscle gains while preserving muscle growth, healing abilities for joints and muscle, lowers cholesterol and raises stamina and endurance. Non toxic (won’t kill your liver  and some Underground sarms have even helped promote a healthy liver),avoids bone loss, decreases the threat of prostate growth in men without mass loss , giving similar effects of testosterone , little to no  estrogen conversion, it’s legal only because it’s still in clinical research.

 

Underground sarms are research chemicals that are designed to help people with muscle wasting diseases and the  obese, to help boost testosterone and even estrogen   also to help support overall health in men and women as an alternative to anabolic steroids. Research chemicals also called experimental chemicals, legal highs, and designer drugs have become more popular than expected due to the legal status they hold as still being under research but sold as not for human consumption and for scientific research purposes only because they are not approved or rejected by the FDA. Research chemicals have mimicked the effects to popular illegal drugs or controlled substances like anabolic steroids and psychoactive substances. The use of many research chemicals is a bit more risky when compared to more commonly prescribed or older drugs used by doctors and on the street. Its is recommended to use harm reduction practices and by that i mean test as low as possible to test threshold and respect the chemical before it puts you in your place or even worse in a hospital or dirt bed.  The safety status of each research chemical is different due to the lack medical study so there is little to no  information on the toxicity, negative health risks and long term side effects or lethal dosages which leads a lot of people in the hospital or dead when playing with legal highs that some mad scientists are pumping out to fill their wallets. Binging on these types  of drugs are strongly discouraged.

So the research I  began with was designer drugs becoming more popular worldwide with mad scientists mimicking   Cannabinoids, Stimulants, Sedatives,Psychedelics, Empathogens, Dissociatives, Nootropics, Sarms, Serms, Peptides.

Cannabinoid legal highs have been around for a real long time just never made popular till media put it on blast making everyone want to try it with the end result of an almost world wide ban due to people getting real ill to the point of death or brain damage due the the lack of respect for the drug. Before its  popularity the mass public knew nothing  about  it but was sold on local head shops  mainly used by people who could not smoke marijuana due to legal issues in their personal life. Spice being the gateway drug for chemical designer drugs opened the possibilities for  other experimental chems to take the stage and abuse for people wanting to abuse and show no respect for these research chemicals. Bath salts got popular real quick having people running around like zombies . Don’t  get me wrong there is still a lot of people that show respect for these chemicals that take it to the lab and tread very carefully on testing thresholds.

Nootropics supplements  have received their own lime lite as people call them the smart drug and the key to unlock the brain . Nootropics are synthetic compounds that help you to accomplish your goals through improved cognition, better recall and crystal-clear focus. These supplements came to the scene to help disorders like Dementia and ADD but found a place in healthy people as a brain enhancer allowing people to focus, remember,  Many Nootropics have limited studies in humans, and the brain itself is still a very unknown organ. Despite the promise of many of these compounds, caution should be exerted to a larger degree when supplementing with some of them. Just like any other chemical it should be respected! So this stuff right here is not considered for the long party nights but instead being used to get an edge on the brain and get ahead on focus and study.

 Serms stands for Selective estrogen receptor modulators. They are new types of pharmaceutical-developed androgen receptor ligands that help bring back your ideal testosterone levels after cycling with pro-hormones and anabolic steroids. Made in 1967 serms was originally created for contraceptives and even though it prevented conception in rats it did the opposite in humans showing it successfully induced ovulation in sub-fertile women and was approved in the U.S for ovary dysfunction for women trying to conceive which led for further uses such as treatment and prevention for breast cancer.

Male bodybuilders, athletes are exploring these supplements as an alternative to testosterone replacement because it has shown to stimulate test in most males restoring it to healthy levels for guys that may have lower than normal test readings. Serms works on the estrogen receptor blocking the effects in certain areas which makes it useful at avoiding or treating anabolic steroid induced gyno aka bitch tits in men.

SERMs bind with estrogen receptors, blocking some estrogen actions while at the same time permitting others. This means their action is different in various tissues, hence the “selective’ descriptor. They selectively inhibit some while stimulating other estrogen-like actions. Compare this to aromatase inhibitors (AI), which block the conversion of androgen into estrogen. In other words, AIs prevent estrogen from being produced while SERMs prevent certain receptors from receiving and responding to estrogen.

Your body is always seeking to maintain balance. When you take a pro-hormone or steroid, your testosterone levels rise. In response to this, your body signals for the release of more estrogen to balance the increase in testosterone. When you end your cycle, testosterone quickly reduces (since it was artificially raised), but it can take some weeks for your body to react and begin reducing estrogen. For a period of time, your body could be pretty far out of whack, with too much estrogen and not enough testosterone. One of the primary effects of this is gynecomastia (the abnormal development of large mammary glands in males resulting in breast enlargement).

One of the problems with AIs is that by blocking estrogen production, levels remain out of balance and the body keeps trying to make more. Sometimes this can cause a rebound effect, so when the AIs is stopped, estrogen levels spike suddenly. This can result in manifestation of some of the adverse androgenic results. Because of this potential rebound effect, many experienced steroid users prefer to use limited (or no) AIs and instead rely on SERMs to block estrogen effects during post cycle therapy.

Peptides a compound consisting of two or more amino acids linked in a chain, the carboxyl group of each acid being joined to the amino group of the next by a bond of the type.

In the bodybuilding industry the term peptides refers to growth hormones and is frowned at by the World Anti-Doping Agency and prohibited for use by athletes and bodybuilders in and out of competition. Even though it’s still on the rise as an alternative and growing more and more popular due to the availability to steroids and legal for experimental and research use.  Inner circles pumping these up as the holy grail to muscle growth  causing mad scientists pumping out new designer peptides to compete with.